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Research11 min readFebruary 9, 2025
Best Appetite Suppressant for Weight Loss
Comparing prescription appetite suppressants. Which medications work best and what are the pros and cons of each option?
By Med Consumer Watch Team
Looking for the most effective appetite suppressant? The landscape has changed dramatically with GLP-1 medications. Here's how the options compare.
Tier 1: GLP-1 Medications
The most effective appetite suppressants available:
- Tirzepatide (Zepbound, Mounjaro) - 20-26% average weight loss, strongest appetite suppression
- Semaglutide (Wegovy, Ozempic) - 15-17% weight loss, highly effective
- Liraglutide (Saxenda) - 5-10% weight loss, older GLP-1
GLP-1 medications work by mimicking natural satiety hormones, making appetite suppression feel natural rather than forced.
Tier 2: Combination Medications
Moderately effective options:
• Qsymia (phentermine/topiramate) - 7-10% weight loss, cognitive side effects
• Contrave (naltrexone/bupropion) - 5-8% weight loss, helps with food cravings
Tier 3: Single-Agent Options
Older, less effective medications:
• Phentermine alone - 5-10% short-term, stimulant side effects, not for long-term use
• Orlistat - Fat blocker, modest weight loss (3-5%), significant GI side effects
The Verdict
For pure appetite suppression effectiveness:
1. Tirzepatide (if available/affordable)
2. Semaglutide
3. Qsymia (if GLP-1s aren't an option)
4. Contrave
5. Phentermine (short-term only)
Consider your health profile, contraindications, cost, and access when choosing.
The Bottom Line
GLP-1 medications are the most effective appetite suppressants available today. Tirzepatide leads, followed by semaglutide. Older options like Qsymia and Contrave remain alternatives for those who can't access or tolerate GLP-1s. Work with your healthcare provider to find the best option for your individual situation.
Sources & References
- Obesity Medicine Association - Pharmacotherapy Guidelines
Medical Disclaimer
This article is for informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare provider before making decisions about your health or medications. Individual experiences may vary.