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Semaglutide Dosage Chart: Injectable and Oral Forms
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Guides8 min readApril 15, 2026

Semaglutide Dosage Chart: Injectable and Oral Forms

Comprehensive semaglutide dosing reference. Comparing Ozempic, Wegovy, and Rybelsus dosing schedules.

By Med Consumer Watch Team
Semaglutide comes in three brand-name forms with different dosing. Here's a comprehensive comparison of Ozempic, Wegovy, and Rybelsus dosing.

Injectable Semaglutide Comparison

Ozempic (diabetes) vs Wegovy (weight loss):
  • Ozempic: 0.25mg → 0.5mg → 1mg → 2mg (max)
  • Wegovy: 0.25mg → 0.5mg → 1mg → 1.7mg → 2.4mg (max)
  • Both: Once weekly injection
  • Wegovy has higher maximum dose and additional titration step

Oral Semaglutide (Rybelsus)

Daily oral dosing: • Weeks 1-4: 3mg daily (initiation) • Week 5+: 7mg daily • Optional: 14mg daily (maximum) Rybelsus has strict requirements: take on empty stomach with ≤4oz water, wait 30 minutes before eating/drinking.

Oral semaglutide has low bioavailability (~1%). The daily 14mg oral dose provides roughly similar exposure to lower injectable doses.

Compounded Semaglutide

Compounding pharmacies often use different dosing: • Common starting: 0.25-0.5mg weekly • Typical titration: Increase 0.25-0.5mg every 4 weeks • Maximum varies by protocol • Quality and dosing accuracy vary by pharmacy

Compounded semaglutide isn't FDA-approved. Dosing may not be directly comparable to brand products.

Dose Equivalence

Approximate comparisons (not exact equivalents): • Injectable doses are more potent mg-for-mg than oral • Wegovy 2.4mg provides maximum weight loss benefit • Ozempic 2mg is maximum for diabetes • Oral semaglutide produces less weight loss than injectable forms

The Bottom Line

Semaglutide dosing varies significantly between products. Wegovy (weight loss) has the highest maximum dose (2.4mg). Ozempic (diabetes) maxes at 2mg. Rybelsus (oral, diabetes) goes up to 14mg daily but produces less weight loss than injectable forms.

Sources & References

  • FDA - Semaglutide Product Prescribing Information

Medical Disclaimer

This article is for informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare provider before making decisions about your health or medications. Individual experiences may vary.

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