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Guides7 min readFebruary 13, 2025
Constipation on GLP-1 Medications: Causes and Solutions
Why GLP-1 medications cause constipation and what you can do about it. Prevention tips and treatment options.
By Med Consumer Watch Team
Constipation is one of the most common side effects of GLP-1 medications like Ozempic, Wegovy, and Mounjaro. Understanding why it happens and how to manage it can significantly improve your quality of life on these medications.
Why GLP-1s Cause Constipation
Several mechanisms contribute:
• Slowed gastric emptying - Food moves more slowly through your entire GI tract
• Reduced food intake - Less food = less bulk moving through intestines
• Dehydration - Eating less often means drinking less, and GI side effects can cause fluid loss
• Changes in gut motility - GLP-1 receptors throughout the GI tract affect movement
Prevention Strategies
Stay ahead of constipation with these approaches:
- Drink plenty of water - 8+ glasses daily
- Eat fiber-rich foods - vegetables, fruits, whole grains
- Stay active - movement stimulates bowel function
- Consider a fiber supplement - psyllium, methylcellulose
- Don't ignore the urge - go when you feel it
Treatment Options
If constipation develops:
• Osmotic laxatives (Miralax, milk of magnesia) - Draw water into bowels
• Magnesium citrate - Effective and may help with other symptoms
• Stool softeners (Colace) - Make stool easier to pass
• Fiber supplements - Add bulk
• Prunes or prune juice - Natural laxative effect
Magnesium citrate is particularly helpful for GLP-1 users—it addresses constipation while providing a mineral many people need more of.
When to See Your Doctor
Contact your provider if:
• No bowel movement for several days
• Severe abdominal pain
• Bloody stool
• Unintentional weight loss beyond medication effect
• Constipation unresponsive to over-the-counter treatments
Severe constipation can rarely lead to bowel obstruction. Don't ignore persistent symptoms.
The Bottom Line
Constipation is a manageable side effect of GLP-1 medications. Prevention through adequate hydration, fiber, and activity is ideal. When constipation occurs, various OTC treatments are effective for most people. Persistent or severe symptoms warrant medical attention.
Sources & References
- American Gastroenterological Association - Constipation Guidelines
Medical Disclaimer
This article is for informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare provider before making decisions about your health or medications. Individual experiences may vary.