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Guides8 min readApril 4, 2026
Tirzepatide vs Semaglutide Cost Comparison
A detailed price comparison of Mounjaro/Zepbound vs Ozempic/Wegovy. Insurance coverage, cash prices, and savings options.
By Med Consumer Watch Team
Both tirzepatide and semaglutide are expensive brand-name medications. Here's a detailed comparison of costs and savings options.
Brand-Name Cash Prices
Without insurance (approximate):
- Ozempic: $900-1,000/month
- Wegovy: $1,300-1,700/month
- Mounjaro: $1,000-1,200/month
- Zepbound: $1,000-1,200/month
Cash prices vary significantly by pharmacy. Always compare prices at multiple pharmacies.
Insurance Coverage
Coverage varies widely:
• Diabetes medications (Ozempic, Mounjaro) often covered with prior auth
• Weight loss versions (Wegovy, Zepbound) rarely covered
• Employer plans vary significantly
• Medicare Part D doesn't cover weight loss medications
• Some state Medicaid programs cover weight loss drugs
Check both the diabetes and weight loss versions with your insurance—coverage may differ substantially.
Manufacturer Savings Programs
Available savings:
• Ozempic savings card: May reduce cost to $25/month with commercial insurance
• Wegovy savings card: Similar savings with eligible insurance
• Mounjaro savings card: As low as $25/month with commercial insurance
• Zepbound savings program: Reduced pricing for eligible patients
These programs don't apply to Medicare or Medicaid.
Compounded Alternatives
Lower-cost options:
• Compounded semaglutide: $200-400/month
• Compounded tirzepatide: $300-500/month
• Available through telehealth providers
• Not FDA-approved; quality varies
• Can be significantly cheaper
Total Cost Comparison
Summary (monthly estimates):
• With good insurance: $25-150/month for either
• Without insurance (brand): $900-1,700/month
• Compounded options: $200-500/month
Tirzepatide and semaglutide are similarly priced at brand level. The real variable is insurance coverage.
The Bottom Line
Tirzepatide and semaglutide have similar brand-name pricing, making insurance coverage the key factor in affordability. Explore manufacturer savings programs, compare pharmacy prices, and consider compounded alternatives if brand medications are unaffordable. Cost shouldn't be the only factor—discuss effectiveness and side effect profiles with your provider.
Sources & References
- GoodRx Drug Pricing Data
Medical Disclaimer
This article is for informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare provider before making decisions about your health or medications. Individual experiences may vary.
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