de-liver-ance Review 2026: A Liver Supplement That Calls Its Side Effects "Detox Effects"

de-liver-ance names its 17 ingredients, which is better than nothing, and its ingredients page writes a paragraph on each. Among them: **Seanol®** (a marine polyphenol from *Ecklonia cava* seaweed), **kudzu**, **ginseng**, **poria**, **turmeric**, **choline**, **white atractylodes**, **redstem wormwood** (*Artemisia scoparia*), **Solomon's seal** and **Chinese salvia** (danshen). What you cannot find anywhere is **how much of any of them the bottle contains**. The formula is a proprietary blend, and no per-ingredient milligram amounts are published. That matters more than it might sound. Across every review we have written this year, the single most useful thing a label can tell you is the dose, because dose is what separates a functional ingredient from a decorative one. We have found lion's mane at a fifteenth of its trial dose, L-carnitine at a fifth, NAC at a third — all in products that named the ingredient proudly. Without numbers, "17 targeted ingredients" is a count, not a formulation. And one ingredient goes further than undisclosed. From the company's own ingredients page: **"The type of Poria used in de-liver-ance is a trade secret."** Poria is *Wolfiporia cocos*, a medicinal fungus. Declining to name which type of a fungal ingredient is in a product that people drink daily, for their liver, is not a reasonable commercial secret to keep from the person swallowing it. If you had an adverse reaction and your hepatologist asked what you had been taking, that answer would not be available to you.

From de-liver-ance's own FAQ, answering whether there are side effects: **"de-liver-ance® is made with natural, high-quality ingredients and is well-tolerated by most people. Some may experience mild detox effects, such as temporary digestive changes or increased hydration needs."** "Detox effects" is one of the most consequential rhetorical moves in wellness marketing, and it is worse here than almost anywhere else it appears. The framing reclassifies adverse effects as evidence of efficacy. If you feel unwell after taking the product, that is not the product disagreeing with you — it is the product working. It teaches the user that the correct response to symptoms is to continue. Now consider what early herb-induced liver injury actually looks like. It typically presents **weeks after starting**, and the early symptoms are **fatigue, nausea, loss of appetite, abdominal discomfort and digestive upset**, progressing to itching, dark urine and jaundice. Those early symptoms are almost exactly what "temporary digestive changes" describes. We are not suggesting de-liver-ance causes liver injury — we have no evidence of that, and no case reports involving this product. We are saying that a liver supplement should be doing the opposite of this: telling users precisely which symptoms mean stop and see a doctor. Instead it tells them that feeling off is part of the process.

de-liver-ance's bundle listings state that the product is **"Fast acting - can reduce toxins by 60%."** The homepage says it is **"clinically shown"** to help, and other marketing describes it as **"clinically proven."** We tried to verify this and could not. The claim does not specify **which toxins**. "Toxins" is not a measurable category — the liver processes ammonia, bilirubin, alcohol, drug metabolites, and thousands of other compounds by entirely different pathways. A 60% reduction in one of those would be a significant clinical finding. A 60% reduction in "toxins" as a general noun is not a measurement at all. It does not specify **how it was measured**, in whom, over what period, or against what comparator. We found no published trial, no journal citation, no clinical trials registry entry, and no linked study. **We are not saying no research exists.** The company references years of research and a patented Seanol ingredient, and Seanol itself does have published work behind it as an antioxidant. What we are saying is that a specific, quantified efficacy claim — 60% — should come with a citation a reader can follow, and this one does not. The same applies to "clinically proven." That is a strong phrase with a specific meaning, and after searching we could not locate the trial that would support it for this finished product.

de-liver-ance contains **Chinese salvia**, better known as **danshen** (*Salvia miltiorrhiza*). Its ingredients page describes it in traditional terms and notes its cardiovascular use. Danshen has one of the best-documented herb–drug interactions in the literature, and it is a dangerous one. **Danshen potentiates warfarin.** Published case reports describe gross over-anticoagulation and bleeding complications in patients on chronic warfarin who took danshen. The mechanism is both pharmacokinetic and pharmacodynamic: danshen increases warfarin absorption, raises its peak concentration and area under the curve, extends its elimination half-life, reduces its clearance, and displaces it from serum albumin — raising free plasma warfarin. It also prolongs prothrombin time directly. The clinical conclusion in the literature is straightforward: **danshen should be avoided in patients taking warfarin.** We found no mention of this on de-liver-ance's ingredients page, in its FAQ, or in its safety information. That is a meaningful omission. Warfarin is still widely prescribed, its therapeutic window is narrow, and over-anticoagulation causes serious bleeding. The population buying a liver supplement skews older and skews toward people with cardiovascular and metabolic conditions — which is the same population most likely to be anticoagulated.

de-liver-ance's FAQ includes the question "Does de-liver-ance® help with hangovers?" and answers it at length, citing **kudzu** for alcohol metabolism, **Seanol** for oxidative stress and neurological fatigue, and **choline** for brain function after drinking. A testimonial on the homepage reads: *"Brought me and friends back to life on numerous occasions."* Two observations. **The kudzu science is real but points the other way.** Kudzu extract has genuine research behind it — but the well-replicated finding is that it **reduces alcohol consumption**, not that it rescues you afterwards. Trials have shown kudzu decreases the number of drinks people consume in a session. That is a legitimately interesting effect. It is not a hangover cure, and the company's framing around acetaldehyde metabolism is a mechanistic hypothesis rather than a demonstrated outcome. **And there is a structural problem with hangover positioning on a liver product.** A product that makes drinking feel more consequence-free, sold on the promise that your liver is being looked after, risks encouraging exactly the behaviour that damages the organ it is named for. Alcohol-related liver disease is the leading cause of liver transplantation in much of the world. Nothing in a $27 shot changes what a heavy night does to hepatocytes. To be fair to the company, this is a secondary framing rather than the main pitch, and the FAQ answer is hedged. But it is on the site, and the testimonial they chose to feature leans into it.

Prices from the live product feed on July 30, 2026. This is one of the more expensive products we have reviewed.

A fair review records these, and there are some. **It names every ingredient and explains each one.** The ingredients page writes a paragraph on all 17, with botanical names, traditional context and some references to published pharmacology. That is more effort than a lot of proprietary-blend brands make, even without doses. **It is honest about what is traditional.** Much of the ingredient copy is explicitly framed as traditional herbal medicine — "used in traditional medicine to deal with the effects of alcohol," "in Traditional Chinese medicine" — rather than dressed up as clinical evidence. Distinguishing traditional use from trial data is the right instinct, and the site does it more often than not. **Seanol is a real, patented ingredient.** *Ecklonia cava* polyphenols have a genuine research literature as antioxidants, and the company says the Seanol in de-liver-ance is patented rather than a generic extract. **There is a named clinician endorsement**, from Dr Yadhu Rajalingam, described as a senior NHS consultant in critical care medicine and anaesthetics at the Royal Free Hospital in London. A named doctor putting their reputation to a quote is more accountable than an anonymous "doctor recommended" badge — though a critical care anaesthetist is not a hepatologist, and an endorsement is not evidence. **Customer sentiment is positive.** The on-site review widget shows 4.9 out of 5 across 153 reviews with 99% recommending. On-site reviews are a self-selected sample collected through the company's own funnel, so weight them accordingly, but the product is clearly well-liked by the people buying it. **The subscription is manageable from the account**, with a "Manage My Subscription" link in the site header rather than buried.

**This might appeal to you if:** you already use traditional herbal preparations, you understand you are buying a traditional formula rather than a clinically validated one, you have no liver condition and take no anticoagulants, and $27 a shot is discretionary spending for you. **Do not take it, or speak to a clinician first, if:** you take **warfarin** or any anticoagulant or antiplatelet drug, because of danshen and turmeric; you have **any diagnosed liver condition** — hepatitis, fatty liver disease, cirrhosis — where adding an undisclosed 17-herb blend is exactly wrong; you are pregnant or breastfeeding; you take prescription medication of any kind, since the liver metabolises most drugs and a proprietary blend makes interactions unassessable; or you are buying it because you are worried about your liver, in which case blood tests come first. **And on the underlying question:** if you want to look after your liver, the interventions with actual evidence are unglamorous and free or cheap. Reduce alcohol. Lose weight if you carry excess, since metabolic dysfunction-associated fatty liver disease is now the most common liver disease in the world. Get vaccinated against hepatitis A and B. Check your medications with a pharmacist, paracetamol in particular. And get liver function tests if you are concerned. No shot does any of that.

**Does de-liver-ance work?** We could not verify its efficacy claims. The company states it is "clinically shown" and "clinically proven," and that it "can reduce toxins by 60%," but we found no published trial, journal citation or registry entry for the finished product, and the 60% claim does not specify which toxins or how they were measured. **What is in de-liver-ance?** Seventeen herbal ingredients in a proprietary blend called Rizasalutem™, including Seanol (*Ecklonia cava*), kudzu, ginseng, poria, turmeric, choline, white atractylodes, redstem wormwood, Solomon's seal and Chinese salvia. **No per-ingredient doses are published**, and the company states that the type of poria used is a trade secret. **Is it safe with my medications?** Ask a pharmacist, and be specific about the danshen. Danshen (Chinese salvia) has well-documented case reports of gross over-anticoagulation and bleeding when combined with warfarin, and the literature recommends avoiding it in warfarin patients. Turmeric also has antiplatelet activity. Because the doses are undisclosed, neither you nor your clinician can assess the magnitude of the risk. **Do liver detox supplements work at all?** A healthy liver detoxifies continuously without help, and there is no good evidence that supplements improve that. Where liver disease exists, it needs diagnosis and treatment. Herbal supplements are, meanwhile, a growing cause of liver injury — 32% of drug-induced liver injury cases in the most recent US network data. **Does it cure hangovers?** The company's FAQ points to kudzu, Seanol and choline. Kudzu's replicated finding is that it reduces how much people drink, not that it treats hangovers. We would not buy it for that purpose. **Are the "detox effects" normal?** This is our main concern with the product's messaging. The FAQ describes "mild detox effects, such as temporary digestive changes" — but digestive upset, nausea, fatigue and appetite loss are also how early herb-induced liver injury presents, typically two to twelve weeks after starting. Do not push through symptoms on the assumption they mean it is working. **How much does it cost?** $27 for a single shot, with pack tiers at $97 and $227 and cases from $464 to $1,221.48. Check the per-shot cost carefully, as the bundle pricing in the product feed is not internally consistent. **Is the company legitimate?** It appears to be a real operating business — Equilibrium Labs, trading in the UK and US, with a named clinician endorsement, a published FAQ, an ingredients page, self-serve subscription management and a visible customer review base. Our concerns are about disclosure and claims, not about whether it exists or ships.