DietWorks GLP-1 Companion Review 2026: A Daily Tablet With Two Stimulant Laxatives In It

Serving size 2 tablets, 30 servings per container. Suggested use: two tablets daily.

The Herbal Digestion Blend, 100 mg, contains five botanicals: ginger root, slippery elm bark, Chinese rhubarb root (Rheum officinale), aloe vera leaf (Aloe barbadensis), and peppermint leaf. Ginger, slippery elm and peppermint are unremarkable digestive botanicals. The other two are not. Chinese rhubarb root contains anthraquinone glycosides. These are stimulant laxatives — the same pharmacological class as senna and cascara. They work by irritating the colonic mucosa and stimulating peristalsis. This is not a gentle prebiotic effect; it is a drug-like action on bowel motility. Aloe vera leaf is the second one. The distinction that matters is between aloe *inner leaf gel*, which is inert and used as a soothing agent, and aloe *latex* — the bitter yellow layer just under the leaf skin — which is also a potent anthraquinone stimulant laxative. The FDA removed aloe from over-the-counter laxative products in 2002 because manufacturers did not supply the safety data required to establish it as generally recognised as safe and effective. The label says "Aloe vera powder (leaf)," which does not tell you whether the latex was removed. Whole-leaf preparations contain it; decolourised inner-leaf preparations largely do not. So the product's headline benefit — "promotes digestion and regularity" — is most plausibly being delivered by two stimulant laxatives, and the label gives you no way to know how much of either you are taking, because they sit inside a 100 mg proprietary blend alongside three other herbs.

The label lists: "BCAA BLEND: Glycine, L-Leucine, L-Valine, L-Isoleucine — 2 g." The branched-chain amino acids are leucine, isoleucine and valine. Three of them. Glycine is not a branched-chain amino acid — it is the smallest and simplest amino acid, with no branched side chain at all. It is also listed first. Supplement blends are labelled in descending order of predominance by weight, which means glycine is the largest single component of the "BCAA blend" — larger than the leucine, and larger than the valine or isoleucine. Glycine is also, by some distance, the cheapest amino acid on the market. So the "2 g BCAA blend" is a blend whose biggest ingredient is not a BCAA, sold under a name that says otherwise. We cannot tell you the split, because the individual amounts are not disclosed. And the underlying premise is shaky even at full strength. The marketing says BCAAs "support muscle endurance" and gut health. For the audience buying this — people on GLP-1 medication, where loss of lean mass is the single biggest nutritional risk — BCAAs are not the right tool. Muscle protein synthesis requires all nine essential amino acids; supplying three of them (or here, arguably fewer) does not sustain it. Complete protein does. For scale: the patient guidance published in *JAMA Internal Medicine* recommends 20–30 g of protein per meal and 1.0–1.5 g per kg of body weight per day. This product provides 2 g of an amino acid blend, most of which appears to be glycine.

Dihydroberberine (GlucoVantage®), 100 mg is the most interesting thing on this label, and it deserves credit. Berberine's central problem, which we have covered across this series, is oral bioavailability under 1%. That is why studied protocols use 500 mg two or three times daily — you need a large amount to absorb a small amount, and it is why so many "berberine" products at 100–400 mg are effectively under-dosed. Dihydroberberine is a reduced form of berberine that is converted back to berberine after absorption, and its supplier NNB Nutrition markets it on the basis of substantially better bioavailability — commonly cited at around five-fold. If that holds, 100 mg of DHB would be roughly equivalent to 500 mg of standard berberine, which would put this at the low end of the studied range rather than far below it. Two honest caveats. The bioavailability multiplier is largely supplier-derived, and the human outcome data for dihydroberberine is much thinner than for berberine itself — most of the clinical literature on glucose and lipids used ordinary berberine. And even at the studied dose, berberine's effect on body weight is small, typically around a couple of kilograms; it is a glucose-and-lipid compound rather than a weight-loss drug. Still: choosing DHB is a formulator recognising a real pharmacokinetic problem and doing something about it. That is more than most of this shelf manages.

Vitamin B6 at 25 mg — 1,471% of the Daily Value. This is below the 100 mg tolerable upper intake level, so it is not alarming, but it is worth knowing that chronic high-dose B6 is associated with peripheral neuropathy — numbness and tingling in the hands and feet. Australia's medicines regulator now requires warning labels on products supplying more than 10 mg a day because of reports at doses well below the old thresholds. If you take other B-complex or fortified products, the totals add up. A "Pro Collagen Blend" containing no collagen. The 100 mg blend is aloe vera leaf, goji fruit extract, rose hips, grape skin extract, Japanese knotweed extract, hyaluronic acid and sodium salt powder. Several of those are reasonable antioxidants — Japanese knotweed is the standard commercial source of resveratrol, and rose hips supply vitamin C, which is a genuine cofactor for collagen synthesis. But a blend named "Pro Collagen" that contains no collagen is going to be read by shoppers as containing collagen. Note that aloe vera leaf appears here too, meaning it is in two of the three blends. Magnesium as magnesium oxide, 50 mg (12% DV). Oxide is the cheap, poorly absorbed form — which is fine if the intent is a laxative effect, but 50 mg is a token amount for either purpose. Colostrum 100 mg, and therefore "Contains: Milk." Worth knowing if you are dairy-allergic, and worth noting that lactose tolerance is often worse on a GLP-1 with slowed gastric emptying. Bacillus subtilis DE111® at 1 billion CFU. Correctly done — a named, trademarked strain quantified in colony-forming units. One billion CFU is a modest dose, but it is an honest and checkable one.

It has a narrow case: if you want a cheap, broadly sensible multivitamin-plus-berberine tablet, you are not sensitive to stimulant laxatives, and you understand what you are getting, $18 is a low-risk experiment by the standards of this category. Skip it if: you are on any medication metabolised through CYP3A4, without checking with a pharmacist first — the berberine matters here; you are pregnant or breastfeeding; or you have kidney disease, take a diuretic, or take digoxin, because of the stimulant laxative and potassium risk. Do not take it daily and indefinitely on the strength of the "regularity" claim. If constipation on a GLP-1 is your problem, the first-line answers are soluble fiber, adequate fluid and, if needed, an osmotic agent such as magnesium citrate or polyethylene glycol — all of which are appropriate for regular use in a way that anthraquinone stimulants are not. And be clear about what "Semaglutide Support" means. It is a marketing phrase on the Amazon listing, not a description of a relationship to the drug. This tablet does not contain semaglutide, does not enhance it, and has not been tested alongside it. If muscle loss is your real concern, which it should be, the answer is on the best GLP-1 supplements page: complete protein at 20–30 g per meal, plus resistance training. Not 2 g of a glycine-led blend.

What is in DietWorks GLP-1 Companion? Per 2 tablets: vitamin C 90 mg, B6 25 mg, B12 500 mcg, calcium 190 mg, magnesium oxide 50 mg, zinc 15 mg, chromium 100 mcg, a 2 g "BCAA blend" led by glycine, colostrum 100 mg, a 100 mg "Pro Collagen Blend," a 100 mg "Herbal Digestion Blend," dihydroberberine 100 mg, CoQ10 15 mg, and Bacillus subtilis DE111 at 1 billion CFU. Does it contain a laxative? The Herbal Digestion Blend contains Chinese rhubarb root and aloe vera leaf, both sources of anthraquinones — the same class of stimulant laxative as senna. Individual amounts are not disclosed. The FDA removed aloe from OTC laxative products in 2002 for lack of submitted safety data. Is it safe to take every day? That is the concern. Stimulant laxatives are not intended for prolonged daily use because of dependence and electrolyte-loss risk, and this product's directions say two tablets daily. If you take it, do not treat it as an indefinite daily supplement without discussing it with a pharmacist. Is the BCAA blend really BCAAs? Partly. Glycine is listed first and is therefore the largest component by weight, and glycine is not a branched-chain amino acid. The three actual BCAAs — leucine, valine and isoleucine — make up the remainder in undisclosed amounts. Is dihydroberberine better than berberine? It is a reasoned choice. Berberine's oral bioavailability is under 1%, and dihydroberberine is marketed as substantially more bioavailable — commonly around five-fold, though that figure is largely supplier-derived and the human outcome data is thinner than for berberine itself. How much does it cost? About $17.99 at Target, $19.99 on Amazon and $27.99 at Walmart for 60 tablets — a 30-day supply. It is the cheapest GLP-1-branded product in our reviews. Does "Semaglutide Support" mean it works with semaglutide? No. It is a marketing phrase. The product contains no semaglutide and has not been tested alongside it. Can I take it with my GLP-1 medication? Ask your prescriber and pharmacist. The berberine can interact with other drugs through CYP3A4 and P-glycoprotein and adds to your medication's glucose-lowering effect, and the laxative botanicals add dehydration and electrolyte risk on top of reduced intake.