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Guides8 min readJuly 24, 2026
Quad by MEDVi Review 2026: The 4-in-1 ED Formula Examined
Our review of Quad by MEDVi's sublingual 4-in-1 ED formula—what's in it, what it costs, and the safety questions to ask before you order.
By Med Consumer Watch Team
Quad is an erectile dysfunction treatment from MEDVi—the same telehealth company behind the GLP-1 weight loss platform we've reviewed separately. It's marketed as "the world's first 4-in-1 formula": a rapid-absorb sublingual liquid combining sildenafil, tadalafil, L-citrulline, and PT-141, prescribed by a US-licensed doctor after an online intake and delivered discreetly. Here's what our research found—including what the landing page tells you, and the important things it doesn't.
What Quad Is and What It Costs
Quad is a compounded sublingual formula that dissolves under the tongue, combining four active ingredients:
- Sildenafil — the active ingredient in Viagra® (a PDE5 inhibitor)
- Tadalafil — the active ingredient in Cialis® (a longer-acting PDE5 inhibitor)
- L-Citrulline — an amino acid supplement associated with nitric-oxide production
- PT-141 (bremelanotide) — a melanocortin-receptor agonist that acts on desire pathways in the brain
Advertised pricing starts at $114/month (listed from $179/month), with the doctor consultation, free rush shipping, 24/7 medical support, and cancel-anytime terms included. Promotional materials elsewhere cite $119/month—confirm the current price at checkout.
How the Process Works
The flow is standard telehealth: a 3-minute online intake form, review by a US-licensed doctor within 24 hours, and delivery in a plain, unmarked package if prescribed. The company advertises that Quad "works in as little as 15 minutes," "lasts 36 hours," and "won't be blocked by food"—note that these are the company's own claims. The 36-hour window is consistent with tadalafil's known duration of action; onset-speed claims for sublingual delivery are marketing figures, not independently verified results.
The Important Part: This Is a Compounded Combination
Sildenafil and tadalafil are each FDA-approved—individually. Quad combines them, plus PT-141, into a single compounded product, and that combination is not an FDA-approved medication. Compounded products are not evaluated by the FDA for safety, effectiveness, or quality. A few specifics worth understanding:
- Taking two PDE5 inhibitors together is not a standard FDA-approved regimen—the combined effect on blood pressure is the main concern
- PT-141 (bremelanotide) is FDA-approved as Vyleesi®, an injection for low sexual desire in premenopausal women—its use in a sublingual men's ED formula is a compounded, off-label application
- PDE5 inhibitors are dangerous with nitrates (e.g., nitroglycerin)—the combination can cause a severe drop in blood pressure—and require caution with alpha-blockers and heart conditions
- Common PT-141 side effects in trials included nausea, flushing, and temporary blood-pressure changes
The Quad landing page we reviewed displayed no contraindication warnings, safety disclosures, or compounded-medication FDA disclaimers. That doesn't mean screening doesn't happen at intake—but it means the burden is on you to disclose all medications (especially nitrates) and heart conditions, and to ask the prescribing doctor about the combination's safety for you specifically.
Company Details
Quad is operated by MEDVi, an established telehealth company whose GLP-1 weight loss platform publishes named partner pharmacies, a named medical network (OpenLoop Health), and a physical address in Newark, Delaware. Quad's own contact channels are hello@medvi.org and (585) 312-4226, with links to terms, privacy, refund, and medical-consent policies—though the refund policy's actual terms aren't shown on the landing page, so get them in writing before subscribing. The page displays a 4.5-star Trustpilot rating (promotional materials cite 4.9); check the live Trustpilot profile yourself and note the review count and dates.
What We Couldn't Find
Our review of Quad's public landing page left these unanswered:
• Which compounding pharmacy prepares the formula
• The actual refund policy terms
• States served
• Any safety warnings, contraindication information, or FDA disclaimers on the page itself
• Exact dosing of each of the four ingredients
Ask about all of these during the consultation—a legitimate prescriber should answer readily.
Is Quad Legit?
Quad comes from an established telehealth operator with real contact channels, a real prescribing process, and cancel-anytime billing—we found no evidence it's a scam. The open questions are about the product category, not the company's existence: this is a compounded, non-FDA-approved four-drug combination whose landing page leans heavily on speed and duration claims while showing none of the safety context. If you're considering it, the single most important step is an honest intake—especially about nitrates, blood-pressure medications, and heart history—and a direct conversation with the prescribing doctor about whether a dual-PDE5 combination is appropriate for you at all.
The Bottom Line
Quad by MEDVi packages four active ingredients into one sublingual ED treatment at $114-$119/month with consultation, rush shipping, and support included—a convenient, aggressively marketed offer from an established telehealth company. The convenience is real; so are the questions. The combination is compounded and not FDA-approved, two PDE5 inhibitors together is not a standard regimen, and the landing page shows no contraindication warnings. Before subscribing: disclose every medication and heart condition at intake, ask which pharmacy compounds the formula and what the per-ingredient doses are, get the refund terms in writing, and talk to your own doctor first. We are not healthcare professionals, and individual results and risks vary.
Sources & References
- Quad by MEDVi — Official Site
- FDA — Compounding and the FDA: Questions and Answers
- FDA — Vyleesi (bremelanotide) Prescribing Information
Medical Disclaimer
This article is for informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare provider before making decisions about your health or medications. Individual experiences may vary.