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Zepbound Dosage Chart: Titration Schedule
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Guides7 min readApril 11, 2026

Zepbound Dosage Chart: Titration Schedule

Complete Zepbound dosing guide. Starting dose, titration schedule, and how to adjust based on your response.

By Med Consumer Watch Team
Zepbound (tirzepatide) is the weight loss-approved version of tirzepatide (also sold as Mounjaro for diabetes). The dosing schedule is identical to Mounjaro.

Zepbound Dosing Schedule

Standard titration:
  • Weeks 1-4: 2.5mg once weekly (starting dose)
  • Weeks 5-8: 5mg once weekly
  • Weeks 9-12: 7.5mg once weekly
  • Weeks 13-16: 10mg once weekly
  • Weeks 17-20: 12.5mg once weekly
  • Week 21+: 15mg once weekly (maximum dose)

Dosing Flexibility

Important considerations: • Increase every 4 weeks OR stay at current dose if it's working • Not everyone needs to reach 15mg • Some patients respond well at lower doses • Slower titration may reduce side effects

Work with your provider to find your optimal dose. The goal is effective weight loss with manageable side effects, not necessarily the maximum dose.

Available Pen Strengths

Zepbound single-dose pens: • 2.5mg • 5mg • 7.5mg • 10mg • 12.5mg • 15mg

Missed Dose Instructions

If you miss your weekly injection: • Within 4 days of missed dose: Take it immediately • More than 4 days: Skip and continue regular schedule • Never take two doses within 3 days of each other

The Bottom Line

Zepbound follows the same titration as Mounjaro—20+ weeks to reach maximum dose. The gradual approach minimizes side effects and helps identify your optimal therapeutic dose.

Sources & References

  • FDA - Zepbound Prescribing Information

Medical Disclaimer

This article is for informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare provider before making decisions about your health or medications. Individual experiences may vary.

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